Texas A & M is a major influence on the business, employment, and housing of the area. TAMU's extensive research programs currently include a nuclear science center and other facilities on what was formerly Bryan Air Force Base. Bryan is also the site of the Brazos Valley Museum of Natural History

Many of the beautiful older homes and buildings around Bryan are listed on the National Register of Historic Places. Established on an original land grant issued to Moses Austin, Bryan has a long history. Moses Austin's son, Stephen F. Austin, encouraged other settlers to settle and farm in the area. His nephew, William J. Bryan became the town's namesake when the City of Bryan, Texas was officially incorporated in 1871.